ChemicalBook CAS DataBase List METHYL 3-CYANO-4-METHOXYBENZOATE

METHYL 3-CYANO-4-METHOXYBENZOATE synthesis

7synthesis methods

Product Name:METHYL 3-CYANO-4-METHOXYBENZOATE
CAS Number:25978-74-9
Molecular formula:C10H9NO3
Molecular Weight:191.18

35450-37-4
114 suppliers
$20.00/10mg

25978-74-9
89 suppliers
$43.00/1g

Yield:25978-74-9 79%

Reaction Conditions:

with copper(l) cyanide in N,N-dimethyl-formamide at 140; for 6 h;

Steps:

8.2 Step 2: Preparation of 3-cyano-4-methoxybenzoic acid methyl ester
To a solution of compound y (1.1 g, 4.4 mol) in dimethylformamide (10 mL) was added cuprous cyanide (1.2 g, 13.2 mmol). And the mixture was heated to 140 ° C for 6 hours. The reaction system was cooled and then ethyl acetate (25 mL) was added. The extracted organic phase was washed with saturated brine and the concentrated residue was dried and concentrated by flash column chromatography (petroleum ether: ethyl acetate = 10: 1) to give a white solid Compound z: Methyl 3-cyano-4-methoxybenzoate (662 mg, yield 79%).

References:

Shanghai Huilun Life Technology Co., Ltd.;Fan Xing;Qin Jihong CN106146504, 2016, A Location in patent:Paragraph 0219; 0220; 0221; 0224; 0225

FullText