ChemicalBook CAS DataBase List methyl 3-(benzyloxy)cyclobutanecarboxylate

methyl 3-(benzyloxy)cyclobutanecarboxylate synthesis

8synthesis methods

Product Name:methyl 3-(benzyloxy)cyclobutanecarboxylate
CAS Number:4934-98-9
Molecular formula:C13H16O3
Molecular Weight:220.26

67-56-1 Synthesis

67-56-1
752 suppliers
$7.29/5ml-f

4958-02-5 Synthesis

4958-02-5
96 suppliers
$29.00/1g

methyl 3-(benzyloxy)cyclobutanecarboxylate

4934-98-9
34 suppliers
$37.00/250mg

Yield: 94%

Reaction Conditions:

with thionyl chloride at 0 - 75; for 16 h;

Steps:

1 Step 1
To a solution of 3-benzyloxycyclobutanecarboxylic acid (10 g, 48.49 mmol, 1 eq) in methanol (100 mL) was added thionyl chloride (11.54 g, 96.98 mmol, 7.03 mL, 2 eq) dropwise at 0 °C, then heated to 75 °C and stirred for 16 h. The reaction mixture was concentrated to give a residue which was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 20/1 to 5/1). Methyl 3-benzyloxycyclobutanecarboxylate (10.13 g, 45.99 mmol, 94% yield) was obtained as a colorless oil.

References:

ARVINAS OPERATIONS, INC. WO2021/11913, 2021, A1 Location in patent:Paragraph 1341; 1342

4934-99-0 Synthesis