ChemicalBook CAS DataBase List METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE

METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE synthesis

4synthesis methods

Product Name:METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE
CAS Number:715-33-3
Molecular formula:C9H8Br2O4
Molecular Weight:339.97

39493-62-4 Synthesis

METHYL 4-HYDROXY-6-METHYL-2-OXO-3-CYCLOHEXENE-1-CARBOXYLATE

39493-62-4
22 suppliers
$20.89/1g

METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE

715-33-3
31 suppliers
$34.39/1g

Yield:715-33-3 93%

Reaction Conditions:

with bromine;acetic acid in methanol at 20 - 45; for 19 h;

Steps:

1.2 (2) Synthesis of 2,4-dihydroxy-3,5-dibromo-6-methylbenzoic acid methyl ester (Compound 3)

After dissolving 15 g (0.081 mol) of compound 2 in 150 mL of glacial acetic acid, 50 mL of a solution of 39 g (0.243 mol) of bromine in glacial acetic acid was added dropwise at 45 ° C for 1 h and then transferred to room temperature for 18 h . The reaction solution was added to ice water, a large number of white solid was precipitated, filtered, the filter cake was collected, dried and the residue was purified by silica gel column chromatography (petroleum ether / acetone) to give a white solid 25g, the yield was 93%.

References:

CN104370738,2017,B Location in patent:Paragraph 0042; 0046; 0047