METHYL 2-METHOXY-4-METHYLBENZOATE synthesis
- Product Name:METHYL 2-METHOXY-4-METHYLBENZOATE
- CAS Number:81245-24-1
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield: 99%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 0; for 1 h;
Steps:
33.1 Step one, compound 2
Compound 1 (7.6 g, 50 mmol) was dissolved in N,N-dimethylformamide (100 mL), and methyl iodide (21.3 g, 150 mmol) was added.After the reaction system was cooled to 0°C, sodium hydride (60%, 6g, 150mmol) was slowly added in batches, stirred for 1 hour, and water (20mL) was added to quench the reaction.The solution obtained above was extracted with ethyl acetate (3x 200mL), the organic phase was washed successively with water (2x 200mL), saturated sodium chloride solution (200mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain compound 2 (yellow oily) Liquid, 9.0g, yield 99%).
References:
CN112939961, 2021, A Location in patent:Paragraph 0424-0428
4670-56-8
174 suppliers
$10.00/1g
74-88-4
347 suppliers
$15.00/10g
81245-24-1
123 suppliers
$42.00/1g
704-45-0
129 suppliers
$14.00/1g
74-88-4
347 suppliers
$15.00/10g
81245-24-1
123 suppliers
$42.00/1g