Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate synthesis
- Product Name:Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate
- CAS Number:1196156-42-9
- Molecular formula:C8H7N3O2
- Molecular Weight:177.16
67-56-1
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$7.29/5ml-f
![5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE](/CAS/GIF/875781-17-2.gif)
875781-17-2
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$7.00/250mg
201230-82-2
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1196156-42-9
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$110.00/50mg
Yield: 46%
Reaction Conditions:
with 1,1'-bis-(diphenylphosphino)ferrocene;palladium diacetate;triethylamine in N,N-dimethyl-formamide at 100; for 12 h;
Steps:
49.1 Step 1. Synthesis of methyl 1H-pyrazole [3,4-b] pyrimidine-5-carboxylic acid ester
5-bromo-1H-pyrazole [3,4-b] pyrimidine (5.0 g, 25 mmol), Pd (OAc) 2 (0.28 g, 1.25 mmol), dppf (1.4 g, 2.5 mmol), methanol (5.0 mL, 125 mmol) and Et3N (7.0 mL, 50 mmol) were added to a 100 mL round bottom flask, dissolved in DMF (15.0 mL), and replaced with CO three times. The reaction was carried out at 100 ° C for 12 hours. After the reaction was completed, it was cooled to room temperature, filtered, spin-dried, and separated by silica gel column chromatography. The obtained yellow solid was the target product (2.0 g, yield: 46%).
References:
Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute;Ding Ke;Li Yupeng;Shen Mengjie;Long Huoyou;Zhang Zhang;Leng Fang;Lu Xiaoyun CN103539784, 2016, B Location in patent:Paragraph 0437-0443
67-56-1
751 suppliers
$7.29/5ml-f
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
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1196156-42-9
73 suppliers
$110.00/50mg
875781-17-2
252 suppliers
$7.00/250mg
1196156-42-9
73 suppliers
$110.00/50mg
875781-15-0
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$6.00/1g
1196156-42-9
73 suppliers
$110.00/50mg