Metalaxyl synthesis
- Product Name:Metalaxyl
- CAS Number:57837-19-1
- Molecular formula:C15H21NO4
- Molecular Weight:279.33
38870-89-2
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![methyl (2R)-2-[(2,6-dimethylphenyl)amino]propanoate](/CAS/20200401/GIF/57646-33-0.gif)
57646-33-0
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57837-19-1
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Yield:57837-19-1 88.2%
Reaction Conditions:
in toluene for 2.5 h;Reflux;
Steps:
1; 2; 3; 4; 5 Example 5
In step S10, 300 kg of methanol and 190 kg of chloroacetic acid (2 kmol) are added to a reaction tank of 3000 L, stirring is started, and the mixture is heated until the material is substantially dissolved, and then 790 kg (4.1 kmol) of 28% sodium methoxide is added, and the temperature is raised to 60 ° C, and the temperature is 1 After the reaction is completed, the methanol is recovered under reduced pressure at a temperature of 78 ° C and a vacuum of 0.098 MPa;Step S20, after the pressure is reduced, the temperature is lowered to 40 ° C, 1500 kg of toluene is added, 100 kg (0.72 kmol) of phosphorus trichloride is added dropwise at 45 ° C, and the dropwise addition is completed in 30 minutes, and the temperature is kept at 55 ° C for 1.0 hour;Step S30, 410kg (95%, 1.88kmol), adding time for 30 minutes, adding reflux and holding for 2 hours, medium-controlled DN-(2,6-dimethylphenyl)alanine methyl ester ≤0.5%, medium After the control is passed, the temperature is lowered to 40 ° C, water is added 800 kg of water to wash twice, layering, toluene is recovered under reduced pressure, the temperature is 109 ° C, and the degree of vacuum is 0.098 MPa;Step S40, after decompression is completed, the temperature is lowered to 60 ° C, 700 kg of water, 450 kg of ethylene glycol are added, the temperature is lowered to 0 ° C for 2 hours, filtered, the filtrate is desolvated, the temperature is 70 ° C, the degree of vacuum is 0.098 Mpa, and the like, no droplets flow out. The temperature is lowered to 70 ° C to obtain the product optically active metalaxyl.
References:
Zhejiang Heben Technology Co., Ltd.;Li Dongliang;Pan Guangfei;Wang Jin;Li Chengbin CN109180514, 2019, A Location in patent:Paragraph 0031; 0036; 0037; 0041; 0046; 0047; 0051; 0056
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52888-49-0
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57837-19-1
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67-56-1
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57837-19-1
265 suppliers
$28.00/50mg