ChemicalBook CAS DataBase List M-CRESOL-D3 (METHYL-D3)

M-CRESOL-D3 (METHYL-D3) synthesis

3synthesis methods

Product Name:M-CRESOL-D3 (METHYL-D3)
CAS Number:25026-32-8
Molecular formula:C7H5D3O
Molecular Weight:111.16

20369-34-0 Synthesis

20369-34-0
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25026-32-8
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Yield:25026-32-8 75%

Reaction Conditions:

with boron tribromide in dichloromethane at -60 - 0;

Steps:

3.2 Step 2 3-(2H3)methylphenol as brown oil:

To a solution of 1-methoxy-3-(2H3)methylbenzene (9 g, 71.89 mmol, 1.00 equiv) in dichloromethane (10 mL) was added BBr3 (144 mL, 2.00 equiv) at -60 °C. The resulting solution was stirred for 2 h at 0 °C. The reaction was then quenched by the addition of water/ice. The resulting solution was extracted with dichloromethane (3 x 50 mL). The organic layers were treated with sodium hydroxide solution (10%). Then the aqueous layers were acidified with hydrogen chloride (1 M), extracted with dichloromethane (3 x 50 mL), dried over anhydrous sodium sulfate and concentrated under vacuum to afford 6 g (75%) of 3-(2H3)methylphenol as brown oil.

References:

WO2016/133989,2016,A1 Location in patent:Paragraph 00180

2398-37-0 Synthesis