Isopropyl acetoacetate synthesis
- Product Name:Isopropyl acetoacetate
- CAS Number:542-08-5
- Molecular formula:C7H12O3
- Molecular Weight:144.17
Yield:542-08-5 95.5%
Reaction Conditions:
with 1,4-diaza-bicyclo[2.2.2]octane at 50 - 90; for 2 h;Reagent/catalyst;Temperature;
Steps:
2 Example 2:
In a 500 ml flask equipped with a stirring, thermometer and reflux condenser,180 g (3.0 mol) of isopropanol and 0.72 g of triethylenediamine were added.The temperature was raised to 50 ° C, and 210 g (2.5 mol) of diketene was added dropwise.The reaction temperature was controlled at 90 ° C during the reaction, and the addition was completed.The temperature was controlled at 90 ° C for 2 hours to terminate the reaction.The crude ester was subjected to vacuum distillation to obtain 344 g of the finished isopropyl acetate.The yield was 95.5% and the content was 99.2%.
References:
Nantong Cusuan Chemical Co., Ltd.;Qing Jiu;Yu Xinnan;Xue Jinquan;Liu Fang;Zhu Xiaogang;Xue Jianfeng;Zhu Aihua CN107840802, 2018, A Location in patent:Paragraph 0038; 0039; 0040; 0042; 0044; 0046; 0048
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