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ChemicalBook CAS DataBase List ISOINDOLINE-5-CARBONITRILE
263888-58-0

ISOINDOLINE-5-CARBONITRILE synthesis

8synthesis methods
263888-56-8 Synthesis
TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE

263888-56-8
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ISOINDOLINE-5-CARBONITRILE

263888-58-0
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Yield: 99.9%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 15; for 2 h;

Steps:

26 Isoindoline-5-carbonitrile
The solution of tert-butyl 5-cyanoisoindoline-2-carboxylate (4.00 g, 16.4 mmol) in TFA/DCM (2M, 100 nil) was stirring at 15 °C lbr 120 miii. After LC-MS showed the reaction was completed, the reaction solution was concentrated to give the title compound (2.36 g, 99.9 %), which was used for the next step directly.

References:

KADMON CORPORATION, LLC;KIM, Ji-in;LIU, Kevin;POYUROVSKY, Masha;LU, Dan;ZHU, Zhenping WO2015/54317, 2015, A1 Location in patent:Paragraph 0276; 0277

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