ChemicalBook CAS DataBase List Fmoc-L-phenylglycine

Fmoc-L-phenylglycine synthesis

4synthesis methods

Product Name:Fmoc-L-phenylglycine
CAS Number:102410-65-1
Molecular formula:C23H19NO4
Molecular Weight:373.4

2935-35-5 Synthesis

2935-35-5
385 suppliers
$5.00/10g

28920-43-6
530 suppliers
$5.00/5g

102410-65-1
216 suppliers
$5.00/1g

Yield:-

Reaction Conditions:

in ethanol;water at 60; for 2 h;

Steps:

1

An unprotected bait, (S)-Aminophenylacetic acid, was protected with (9H- Fluoren-9-yl)methyl chloroformate (Fmoc chloride). To the mixture of the two solids, (S)- Aminophenylacetic acid (1 mmol) and Fmoc chloride (1.2 mmol), 1.5 mL of a 3:1 mixture of water to ethanol was added. The resulting solution was stirred at 60 C for 2 hours. The solution was acidified with HCl (1M) until pH 4-5 at O C and extracted with EtOAc (3 X 10 mL). The combined organic layers were merged dried over sodium sulfate and concentrated in vacuo to afford the protected bait, (S)-[(9H-Fluoren-9-yl)methoxycarbonyl- amino]phenylacetic acid. In this example the protected bait can also be purchased commercially from a number of vendors.

References:

WO2021/167770,2021,A1 Location in patent:Paragraph 00153-00154

2935-35-5 Synthesis

2935-35-5
385 suppliers
$5.00/10g

82911-69-1 Synthesis