天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Fialuridine
69123-98-4

Fialuridine synthesis

8synthesis methods
-

Yield: 91.8%

Reaction Conditions:

Stage #1:5-iodo-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)uracil with water;sodium hydroxide in tetrahydrofuran for 4 h;
Stage #2:Acidic conditions;

Steps:

5.3.2
8.14 (14.03 mmol) 5-iodo-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)uracil are dissolved in 250 ml THF and mixed with 50 ml (100 mmol) 2 M sodium hydroxide solution. After 4 h the reaction is terminated. The solution is neutralised and extracted several times with acetic ester. The combined extracts are dried with magnesium sulphate. After filtration and centrifugation of the solvent, purification by column chromatography is effected (chloroform/methanol 10:1). 4.80 g (91.8%) of a colourless solid is obtained.

References:

RESprotech GmbH US2010/227834, 2010, A1 Location in patent:Page/Page column 18

Fialuridine Related Search: