ETHYL 4-CHLORO-8-FLUOROQUINOLINE-3-CARBOXYLATE synthesis
- Product Name:ETHYL 4-CHLORO-8-FLUOROQUINOLINE-3-CARBOXYLATE
- CAS Number:56824-90-9
- Molecular formula:C12H9ClFNO2
- Molecular Weight:253.66
63010-69-5
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56824-90-9
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Yield:-
Reaction Conditions:
with trichlorophosphate at 100; for 3.5 h;
Steps:
A mixture of 8-fluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester (6.11 g, 26.0 mmol; see step (b) above) and POCl3 (20 mL) was stirred at 100 °C for 3.5 h, cooled and concentrated to give a yellow semi-solid (9.85 g) which was used without purification.1H-NMR (CDCl3, 400 MHz) δ 9.58 (IH, s), 8.46 (IH, d), 8.04-7.90 (2H, m), 4.60 (2H5 q), 1.54 (3H, t).
References:
WO2007/51982,2007,A1 Location in patent:Page/Page column 44
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63010-68-4
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$28.60/250mg
56824-90-9
45 suppliers
$75.09/250mg
87-13-8
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$5.00/5g
56824-90-9
45 suppliers
$75.09/250mg
348-54-9
417 suppliers
$10.00/1g
56824-90-9
45 suppliers
$75.09/250mg