ChemicalBook CAS DataBase List Ethyl 3-bromo-2-oxobutyrate

Ethyl 3-bromo-2-oxobutyrate synthesis

3synthesis methods

Product Name:Ethyl 3-bromo-2-oxobutyrate
CAS Number:57332-84-0
Molecular formula:C6H9BrO3
Molecular Weight:209.04

15933-07-0 Synthesis

15933-07-0
122 suppliers
$8.00/1g

57332-84-0
86 suppliers
$30.00/100mg

Yield:57332-84-0 97%

Reaction Conditions:

with bromine in dichloromethane at 5 - 20;

Steps:

1.A
Step A: Ethyl 3-bromo-2-oxobutanoate (1-B). To a solution of compound 1-A (4.8 g, 36.9 mmol) in CH₂Cl₂ (20 mL), cooled to 5° C., was added bromine (1.89 mL, 36.9 mmol), drop-wise. The reaction mixture was allowed to warm to room temperature and stir for 18 h. The reaction mixture was purged with nitrogen, diluted with EtOAc, and the organic phase washed with 10% NaHCO₃ (2*), H₂O, brine, dried over Na₂SO₄, filtered and the solvent evaporated under reduced pressure to afford compound 1-B as a yellow oil (7.50 g, 97%). ¹H-NMR (CDCl₃): δ 5.15-5.20 (q, 1H), 4.32-4.45 (m, 2H), 1.82-1.85 (d, 3H), 1.38-1.41 (t, 3H).

References:

Macielag, Mark J.;Xia, Mingde;McNally, James J.;Matthews, Jay M. US2012/149699, 2012, A1 Location in patent:Page/Page column 14-15

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