天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

73017-82-0

ETHYL 2-(METHYLSULFONYL)PROPANOATE synthesis

2synthesis methods
-

Yield:73017-82-0 84.89%

Reaction Conditions:

in ethanol at 77; for 20 h;Inert atmosphere;Large scale;

Steps:

1.a

A solution of ethyl 2-chloropropanoate (1000 g, 7.35 mol) and sodium methanesulfinate (899 g, 8.82 mol) in ethanol (1350 mL) was stirred at 77 °C for 20 hrs. The reaction mixture was allowed to cool to r.t. The solids were removed by filtration through celite, and the filter pad was washed with ethanol. The filtrates were combined and concentrated in vacuo. The crude product was suspended in EtOAc and H20. The organic phase was washed by brine, dried over Na2S04, filtered, concentrated to give ethyl 2-(methylsulfonyl)propanoate (1124 g, 84.9%) as a yellow oil. 1HNMR: 400 MHz CDCI3δ: 4.25-4.28 (m, 2H), 3.84-3.90 (m, 1 H), 3.04 (s, 3H), 1 .63-1 .65 (m, 3H), 1 .29-1 .33 (m, 3H). Part B

References:

WO2017/98440,2017,A1 Location in patent:Page/Page column 109