ChemicalBook CAS DataBase List ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE

ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE synthesis

10synthesis methods

Product Name:ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE
CAS Number:5408-04-8
Molecular formula:C6H9NO4
Molecular Weight:159.14

141-97-9 Synthesis

141-97-9
790 suppliers
$5.00/25g

5408-04-8
67 suppliers
$32.00/500mg

Yield:5408-04-8 99%

Reaction Conditions:

Stage #1: ethyl 3-oxobutanoatewith glacial acetic acid;NaNO₂ in lithium hydroxide monohydrate at 0;
Stage #2: with Sodium hydrogenocarbonate in lithium hydroxide monohydrate; pH=7 - 8;

Steps:

10.1

To a solution of compound 1 (5.20 g, 40.0 mmol) in 6 ml AcOH was added a solution of NaNC-2 (3.60 g, 52.0 mmol) in 6 ml water at 0°C. After stirred at 0°C for overnight, saturated aqueous solution of NaHCC?3 was added to adjust pH to 7-8, then brine was added, and the mixture was extracted with ethyl acetate, dried by anhydrous Na2S04, concentrated to afford compound 27 (6.35 g , 99% yield).

References:

WO2012/144661,2012,A1 Location in patent:Page/Page column 84

998-91-4 Synthesis