ERYTHROMYCIN OXIME synthesis
- Product Name:ERYTHROMYCIN OXIME
- CAS Number:13127-18-9
- Molecular formula:C37H68N2O13
- Molecular Weight:748.94
7704-67-8
328 suppliers
$59.00/5g
13127-18-9
197 suppliers
$49.00/100mg
Yield:13127-18-9 89 g
Reaction Conditions:
with hydroxylamine hydrochloride;ammonium bicarbonate;sodium iodide in methanol at 56 - 60;Reagent/catalyst;
Steps:
2 Preparation of erythromycin A oxime
Hydroxylamine hydrochloride 44g, erythromycin thiocyanate 100g, sodium iodide 3g added 110ml of methanol, and then slowly added 2g bicarbonate amine, warmed to 56-60 ° C for 8-10h, the solvent was concentrated under reduced pressure, was added 400ml Ethyl acetate, adding 20% by mass aqueous sodium hydroxide solution to adjust the pH of the reaction solution to 10-11, discarding the aqueous layer, washing the organic layer with an appropriate amount of water 2-3 times and concentrating to dryness in vacuo to obtain a white solid, Dried, erythromycin A oxime 89g, HPLC purity of 98.04%, molar yield of 96%
References:
Heze Fangming Pharmaceutical Co., Ltd.;Yang Shaobo;Sun Xiuwei;Wang Wenzhao;Zhang Guoqing CN106957348, 2017, A Location in patent:Page/Page column 5
114-07-8
741 suppliers
$5.00/250mg
13127-18-9
197 suppliers
$49.00/100mg
114-07-8
741 suppliers
$5.00/250mg
13127-18-9
197 suppliers
$49.00/100mg
105882-69-7
76 suppliers
$95.00/1mg