ChemicalBook CAS DataBase List ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE

ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE synthesis

6synthesis methods

Product Name:ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE
CAS Number:388071-27-0
Molecular formula:C15H19F2NO3
Molecular Weight:299.32

(1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

388072-80-8
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ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE

388071-27-0
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$95.20/25MG

Yield:388071-27-0 90%

Reaction Conditions:

with potassium hydroxide in ethanol at 0; for 2 h;

Steps:

49

A solution of tert-butyl (1 S, 2S)-3-chloro-1- (3, 5-diflurorbenzyl)-2- hydroxypropylcarbamate in ethanol (150 mL) was cooled to 0 °C. A solution of KOH in EtOH (25 mL) was added. The reaction was removed from the ice bath and stirred for 2 h. The reaction was diluted with 300 mL of water and placed into an ice bath. The resulting solid was collected by filtration and washed with cold water (100 mL). Drying overnight gave an off-white solid (6.74g, 22.51 mmol, 90%).

References:

WO2005/70407,2005,A1 Location in patent:Page/Page column 193