epsilon-dinitrophenyllysine synthesis
- Product Name:epsilon-dinitrophenyllysine
- CAS Number:1094-76-4
- Molecular formula:C12H16N4O6
- Molecular Weight:312.28
![L-Lysine, N6-(2,4-dinitrophenyl)-N2-[[1-methyl-2-(phenylsulfonyl)ethoxy]carbonyl]-](/CAS/20210305/GIF/1202639-02-8.gif)
Yield:-
Reaction Conditions:
with water;acetic acid in methanol at 37; pH=7.4;Kinetics;
Steps:
1
The rates of release of NE-2,4-dinitrophenyl-L-lysine from these compounds were determined at pH 7.4 or pH 8.3, 37°C, by HPLC analysis. Kinetic analyses of the release reactions were performed by HPLC (C18; linear MeOH/water + 0.5% HOAc gradient) using a UV/vis monitor at 350 nm. The areas under the Lys(DNP) ("P") and starting material ("S") peaks were integrated to determine extent of reaction("R") as R = P/(S+P). Reaction rates were calculated from the slope the line obtained by linear regression analysis of a plot of ln(l-R) versus time. The t]/2 values of β-eliminative cleavage of DNP-Lys carbamates at pH 7.4 and/or 8.3 are shown in Table 2.
References:
WO2011/140392,2011,A1 Location in patent:Page/Page column 31-32
![L-Lysine, N2-[(2-cyanoethoxy)carbonyl]-N6-(2,4-dinitrophenyl)-](/CAS/20210305/GIF/1202639-11-9.gif)
![L-Lysine, N2-[(2-cyano-1-methylethoxy)carbonyl]-N6-(2,4-dinitrophenyl)-](/CAS/20210305/GIF/1202639-12-0.gif)
