ChemicalBook CAS DataBase List Epifluorohydrin

Epifluorohydrin synthesis

3synthesis methods

Product Name:Epifluorohydrin
CAS Number:503-09-3
Molecular formula:C3H5FO
Molecular Weight:76.07

106-89-8 Synthesis

106-89-8
752 suppliers
$9.00/10 g

503-09-3
71 suppliers
$40.00/1 g

Yield: 88%

Reaction Conditions:

with C₆H₁₁BFO₃^(1-)*K⁽¹⁺⁾ in N,N-dimethyl-formamide at 85; for 2 h;

Steps:

33
EXAMPLE 33 This example and the following two examples illustrate the use of the complexes of the invention for “Halex”-type chlorine→fluorine exchanges in which the complex is used in a stoichiometric amount so as to allow reactions which are impossible with the prior art owing to the sensitivity of the substrates to the elimination reactions.20 g of epichlorohydrin and 44 g of K⁺[C₂H₅C(CH₂O)₃BF]^-, which is the adduct formed by the IB-2 compound with KF, are added to 150 ml of DMF and brought to 85° C. KCl is gradually formed and the reaction mixture is filtered after two hours of stirring. 14 g of epifluorohydrin (88% yield) are obtained by precipitation from 500 ml of water and then filtration.

References:

Armand, Michel;Tarascon, Jean-Marie;Recham, Nadir;Grugeon, Sylvie;Laruelle, Stephane;Devaraj, Shanmukaraj US2011/171112, 2011, A1 Location in patent:Page/Page column 23