Difloxacin synthesis
- Product Name:Difloxacin
- CAS Number:98106-17-3
- Molecular formula:C21H19F2N3O3
- Molecular Weight:399.39
704-10-9
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98106-17-3
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Yield:-
Steps:
Multi-step reaction with 6 steps
1: 80 percent / NaH / 1.5 h / 80 °C
2: Ac2O / 2 h / 130 °C
3: CH2Cl2 / 0.5 h / Ambient temperature
4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C
5: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C
6: 21.3 g / various solvent(s) / 24 h / 110 °C
References:
Chu, Daniel T. W.;Fernandes, Prabhavathi B.;Claiborne, Akiyo K.;Pihuleac, Eva;Nordeen, Carl W.;et al. [Journal of Medicinal Chemistry,1985,vol. 28,# 11,p. 1558 - 1564]
86483-51-4
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98106-17-3
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98105-80-7
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![Benzenepropanoic acid, 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxo-, ethyl ester](/CAS/20210305/GIF/98105-65-8.gif)
98105-65-8
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98106-17-3
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86483-52-5
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98106-17-3
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