DIETHYL 2,4-DIFLUOROPHENYL MALONATE synthesis
1synthesis methods
- Product Name:DIETHYL 2,4-DIFLUOROPHENYL MALONATE
- CAS Number:137186-30-2
- Molecular formula:C13H14F2O4
- Molecular Weight:272.24
Yield:137186-30-2 68%
Reaction Conditions:
Stage #1: diethyl malonatewith sodium hydride in 1,4-dioxane;mineral oil at 60; for 0.166667 h;Inert atmosphere;
Stage #2: 2,4-difluorobromobenzenewith copper(I) bromide in 1,4-dioxane;mineral oil at 100; for 12 h;Inert atmosphere;
References:
Oukoloff, Killian;Nzou, Goodwell;Varricchio, Carmine;Lucero, Bobby;Alle, Thibault;Kovalevich, Jane;Monti, Ludovica;Cornec, Anne-Sophie;Yao, Yuemang;James, Michael J.;Trojanowski, John Q.;Lee, Virginia M.-Y.;Smith, Amos B.;Brancale, Andrea;Brunden, Kurt R.;Ballatore, Carlo [Journal of Medicinal Chemistry,2021,vol. 64,# 2,p. 1073 - 1102]