desmethylmianserin synthesis

6synthesis methods

Product Name:desmethylmianserin
CAS Number:71936-92-0
Molecular formula:C17H18N2
Molecular Weight:250.34

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71936-92-0
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Yield:-

Steps:

Multi-step reaction with 10 steps
1: methanol / 2 h / 60 °C
2: palladium diacetate; 1,4-di(diphenylphosphino)-butane; potassium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere
3: ammonium formate; palladium 10% on activated carbon / methanol / 15 h / Reflux
4: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Reflux
5: manganese(IV) oxide / toluene / 24 h / 110 °C
6: potassium tert-butylate / water / 48 h / 25 °C
7: nickel dichloride; sodium tetrahydroborate; methanol / 1 h / 0 °C
8: dichloromethane / 2 h / 0 °C
9: sodium iodide; sodium hydrogencarbonate / acetone / 72 h / 70 °C
10: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

References:

Huang, Xueliang;Ma, Liyao;Xia, Jiajin;Xin, Luoting;Yu, Yinghua;Zhu, Lei [Angewandte Chemie - International Edition,2020,vol. 59,# 41,p. 18261 - 18266][Angew. Chem.,2020,vol. 132,# 41,p. 18418 - 18423,6]