性感美女视频大全,免费街拍美女视频在线网观看,美女视频美国

411235-57-9 Synthesis

411235-57-9
437 suppliers
$6.00/1g

16545-68-9
109 suppliers
$70.00/100 mg

-

Yield:16545-68-9 60%

Reaction Conditions:

with dihydrogen peroxide;sodium hydroxide in water at 5; for 1 h;

Steps:

1 Step 1: cyclopropanol
Step 1: cyclopropanol (0104) (0105) Cyclopropylboronic acid (10g, 0.116mol), sodium hydroxide aqueous solution (8.37g, 0.209mol, added to 100ml water) were added into a 1L reaction flask, and hydrogen peroxide (34%, 80mL) was slowly dropped thereinto under ice bath and the temperature was kept not higher than 5°Cduring the process of dropping. After adding, the mixture was stirred at 5°C for 1 hour. After completion of the reaction, a saturated sodium thiosulfate aqueous solution was slowly dropped to terminate the reaction until the potassium iodide-starch test paper does not change color. The reaction solution was extracted with diethyl ether for three times and the combined organic phase was washed with saturated brine, dried, filtered and concentrated at 0°C to obtain the title compound (colorless oil, 4g, 60%), which may be used directly for the subsequent reaction. (MS: [M+1] none)

References:

Beijing Pearl Biotechnology Limited Liability Company;DONG, Jiaqiang;ZHONG, Boyu;YUAN, Hongbin;SHI, Quan;CHU, Shaosong;ZHANG, Deyi;ZHANG, Ruihao EP3150592, 2017, A1 Location in patent:Paragraph 0103; 0104; 0105

FullText

75-19-4 Synthesis