Cefotaxime Impurity 39 synthesis
- Product Name:Cefotaxime Impurity 39
- CAS Number:66341-09-1
- Molecular formula:C6H7N3O3S
- Molecular Weight:201.2
69689-85-6
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Yield:-
Reaction Conditions:
in sodium hydroxide;water
Steps:
9.8 Preparation 9
(8) Ethyl 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate hydrobromide (anti isomer) (15.5 g.) was dissolved in a solution of sodium hydroxide (4.4 g.) in water (150 ml.) and the resulting solution was stirred for 1 hour at ambient temperature. An insoluble material was filtered off and the filtrate was adjusted to pH 5.0 to precipitate crystals. The crystals were collected by filtration and dried to give 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (anti isomer) (8.0 g.). I.R. spectrum (Nujol) 3150, 1655, 1595, 1550 cm-1
References:
Fujisawa Pharmaceutical Co., Ltd. US4279818, 1981, A