BOC-CYS-OH synthesis
- Product Name:BOC-CYS-OH
- CAS Number:20887-95-0
- Molecular formula:C8H15NO4S
- Molecular Weight:221.27
52-90-4
916 suppliers
$6.00/10g
24424-99-5
835 suppliers
$13.50/25G
20887-95-0
162 suppliers
$27.00/250mg
Yield:20887-95-0 97%
Reaction Conditions:
with sodium hydroxide in 1,4-dioxane;water at 20;Cooling with ice;
Steps:
1.1 Step 1: Preparation of N-Boc-L-cysteine (1)
Add L-cysteine (6.0 g, 50 mmol), NaOH (1.2 g, 50 mmol),Dioxane (30 mL) and water (50 mL), (Boc) 2O (17.0 g, 70 mmol) were added under an ice bath, and stirring was continued at room temperature overnight. Concentrated under reduced pressure to remove dioxane,The aqueous layer was extracted with ethyl acetate to remove unreacted Boc anhydride.The aqueous layer was adjusted to pH 1-2 with 1 mol / L hydrochloric acid, and extracted twice with ethyl acetate.The organic phases were combined and washed with saturated brine, dried over anhydrous sodium sulfate,Concentrated under reduced pressure to obtain 2.15 g (1) as a colorless syrup, with a yield of 97%.Directly used for the next reaction
References:
Fudan University;Chu Yong;Gao Yang;Ye Deyong CN110407770, 2019, A Location in patent:Paragraph 0036-0040
10389-65-8
131 suppliers
$14.00/5G
20887-95-0
162 suppliers
$27.00/250mg
5068-28-0
232 suppliers
$9.00/10g
20887-95-0
162 suppliers
$27.00/250mg
19746-37-3
211 suppliers
$6.00/1g
20887-95-0
162 suppliers
$27.00/250mg
61925-77-7
159 suppliers
$9.00/1g
20887-95-0
162 suppliers
$27.00/250mg