ChemicalBook CAS DataBase List BIS(2-CYANOETHYL)-N,N-DIISOPROPYL PHOSPHORAMIDITE

BIS(2-CYANOETHYL)-N,N-DIISOPROPYL PHOSPHORAMIDITE synthesis

8synthesis methods

Product Name:BIS(2-CYANOETHYL)-N,N-DIISOPROPYL PHOSPHORAMIDITE
CAS Number:102690-88-0
Molecular formula:C12H22N3O2P
Molecular Weight:271.3

921-26-6 Synthesis

921-26-6
87 suppliers
$80.00/1g

109-78-4 Synthesis

109-78-4
369 suppliers
$10.00/1g

BIS(2-CYANOETHYL)-N,N-DIISOPROPYL PHOSPHORAMIDITE

102690-88-0
137 suppliers
$29.00/100mg

Yield:-

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in dichloromethane;

Steps:

4.10. Preparation of bis(2-cyanoethyl) N,N-diisopropylaminophosphoramidite

(Diisopropylamino)dichlorophosphine was prepared by the method of Uhlmann and EngelsrefPreviewPlaceHolder¹¹ by adding two equivalents of diisopropylamine to a solution of phosphorus trichloride in dry ethyl ether at -78 °C. The crude product was purified by distillation under reduced pressure and could be stored as a crystalline solid at -20 °C. Two equivalents of 2-cyanoethanol were reacted with the purified product in dehydrated CH₂Cl₂ in the presence of diisopropylethylamine to afford bis (2-cyanoethyl) N,N-diisopropylaminophosphoramidite.

References:

Anraku, Kensaku;Inoue, Teruhiko;Sugimoto, Kenji;Kudo, Kota;Okamoto, Yoshinari;Morii, Takashi;Mori, Yasuo;Otsuka, Masami [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 22,p. 6833 - 6841] Location in patent:experimental part

102691-36-1 Synthesis