BINDONE synthesis
- Product Name:BINDONE
- CAS Number:1707-95-5
- Molecular formula:C18H10O3
- Molecular Weight:274.27
Yield: 89%
Reaction Conditions:
with pyridine in ethanolReflux;Knoevenagel Condensation;
Steps:
Synthesis of 2-((1H-pyrrol-2-yl)methylene)-1H-indene-1,3(2H)-dione (PP6)
Indane-1,3-dione (6.50 g, 44.47 mmol, M = 146.14 g/mol) and 1H-pyrrole-2-carbaldehyde (4.22 g, 44.47mmol, M = 95.10 g/mol) were dissolved in ethanol (50 mL) and a few drops of pyridine were added.The solution was heated at reflux overnight, providing a precipitate. After cooling, it was filtered off,washed several times with ethanol and pentane, and dried under vacuum. The reaction product wasidentified as bindone, the product resulting from the self-condensation of indane-1,3-dione (5.43 g,89% yield, grey solid).
References:
Bonardi, Aude-Héloise;Dumur, Frédéric;Duval, Sylvain;Gigmes, Didier;Lalevée, Jacques;Noirbent, Guillaume;Xu, Yangyang [Molecules,2020,vol. 25,# 10] Location in patent:supporting information
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