benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate synthesis
- Product Name:benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
- CAS Number:1027135-00-7
- Molecular formula:C18H19FN2O3
- Molecular Weight:330.3535
Yield:1027135-00-7 99.1%
Reaction Conditions:
with potassium carbonate in tetrahydrofuran at 20; for 2 h;Inert atmosphere;
Steps:
5 Typical procedure for synthesis of allyl phenylcarbamate
General procedure: To a flame-dried screw-caped reaction tube was added a mixture of the amine (1.84 g, 20.00 mmol), powdered K2CO3 (3.31 g, 24.00 mmol, 1.20 equiv), and benzyl carbonochloridate (3.14 mL, 22.00 mmol, 1.10 equiv) in 100 mL of anhydrous THF under argon. ;Then the resulting mixture was stirred for 2 h at room temperature, and the product was extracted with methylene chloride (100 mL) and washed with saturated Na2CO3 (50 mL*3). ;The organic layer was dried over anhydrous Na2SO4 and filtered. ;The solvent was then removed under reduced pressure, and the residue was purified by silica-gel chromatography (EtOAc/petroleum ether=1:4), providing 3a (4.09 g) as a white solid.
References:
Yang, Bo;Shi, Luyan;Wu, Jingjing;Fang, Xiang;Yang, Xueyan;Wu, Fanhong [Tetrahedron,2013,vol. 69,# 15,p. 3331 - 3337] Location in patent:supporting information
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