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103037-96-3

Benzothiazole, 2-acetamido-5-methyl- (6CI) synthesis

3synthesis methods
-

Yield:103037-96-3 92%

Reaction Conditions:

for 0.00277778 h;Green chemistry;

Steps:

General procedure for the synthesis of acetamides 3a-p,5a-d, and 7

General procedure: To a 10 mL round bottom flask was added 0.5 mmolof the amine and 0.1 mL of acetic anhydride. The reactionis instantaneous and exothermic, and after 10 s the solidproduct formed was filtered and washed with cold water.When no solid was immediately formed, 4 mL of coldwater was added, and the mixture allowed standing ina refrigerator for 24 h, leading to precipitation. To allsynthesized acetamides, measured physical data were inagreement to the reported values.17-19,27,31,32

References:

Cunha, Silvio;De Santana, Louren?o L. B. [Journal of the Brazilian Chemical Society,2017,vol. 28,# 6,p. 1137 - 1144]