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202522-04-1

Benzonitrile, 3-ethyl-4-formyl- (9CI) synthesis

4synthesis methods
-

Yield:202522-04-1 26%

Reaction Conditions:

Stage #1: 4'-amino-3'-ethylbenzonitrilewith hydrogenchloride;sodium nitrite in water at 0; for 0.5 h;
Stage #2: with sodium acetate;1,3,5‐trihydroxy‐1,3,5‐triazinan‐1‐ium chloride;copper(II) sulfate;sodium sulfate in water at 0;

References:

Briard, Emmanuelle;Rudolph, Bettina;Desrayaud, Sandrine;Krauser, Joel A.;Auberson, Yves P. [ChemMedChem,2015,vol. 10,# 6,p. 1008 - 1018]