ChemicalBook CAS DataBase List Benzo[b]thiophene-3-carboxylic acid methyl ester

Benzo[b]thiophene-3-carboxylic acid methyl ester synthesis

13synthesis methods

Product Name:Benzo[b]thiophene-3-carboxylic acid methyl ester
CAS Number:22913-25-3
Molecular formula:C10H8O2S
Molecular Weight:192.23

67-56-1 Synthesis

67-56-1
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$9.00/25ml

5381-25-9
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$8.00/250mg

Benzo[b]thiophene-3-carboxylic acid methyl ester

22913-25-3
27 suppliers
$206.00/1g

Yield:22913-25-3 380 mg

Reaction Conditions:

with oxalyl dichloride at 80; for 2 h;Cooling with ice;

Steps:

10 Production example 10

Production example 10
370 mg of oxalyl chloride was added to a mixture of 400 mg of benzo[b]thiophene-3-carboxylic acid and 20 ml of methanol under ice cooling. This mixture was stirred for 2 hours at 80°C. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Tert-butyl methyl ether was added to the residues, and the residue was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline. The organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, thereby obtaining 380 mg of methyl benzo[b]thiophene-3-carboxylate (hereinafter, described as a "compound 12 of the present invention").¹H-NMR (CDCl₃) δ: 8.60 (m, 1H), 8.39 (s, 1H), 7.88 (m, 1H), 7.49 (m, 1H), 7.43 (m, 1H), 3.97 (s, 3H)

References:

EP2923573,2015,A1 Location in patent:Paragraph 0222; 0223

7342-82-7 Synthesis