ChemicalBook CAS DataBase List bellidifolin

bellidifolin synthesis

5synthesis methods

Product Name:bellidifolin
CAS Number:2798-25-6
Molecular formula:C14H10O6
Molecular Weight:274.23

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Yield:2798-25-6 62%

Reaction Conditions:

with sodium hydride in acetone at -5 - 20; for 11 h;

Steps:

3 synthesis of bellidifolin
In a 50 mL single-necked flask,Add 10 mL of acetone,1,3,5,8-tetrahydroxytoxone 0.13 gAnd 0.11 g of methyl iodide,Ice bath cooling system internal temperature of -5 ,0.04 g of sodium hydride was added with stirring,After maintaining this temperature reaction for 1 h,Rose to room temperature reaction 10h,Add 10 mL of ice water to quench the reaction,After extraction with 10 mL * 2 with ethyl acetate,The organic phase was washed twice with water,After drying,Column chromatography,Eluent petroleum ether / ethyl acetate = 2/1,A pale yellow solid, 0.085 g,Yield 62%.

References:

Tianjin Agricultural University;SHANG, Zhi-qiang;QI, Bangda;LU, Li-juan;XU, Yan-ling CN106565660, 2017, A Location in patent:Paragraph 0011; 0012

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