B-CYANOETHYL METHACRYLATE synthesis
- Product Name:B-CYANOETHYL METHACRYLATE
- CAS Number:4513-53-5
- Molecular formula:C7H9NO2
- Molecular Weight:139.15
109-78-4
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Yield: 64%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 10 h;Inert atmosphere;Cooling with ice;
Steps:
10 Example 10. Synthesis of Compound m-CN-1 Monomer
Dissolve 3-hydroxypropionitrile (1.4 g, 20 mmol) in 30 mL of anhydrous DCM.Add 8 mL (60 mmol) of dry TEA, pass N2 protection,Methacryloyl chloride (3.3 mL, 34 mmol) was added dropwise to the solution in an ice bath. After the addition was completed, the reaction was allowed to proceed to room temperature for 10 h. The reaction solution was extracted with DCM and washed twice with saturated NaHCO3 solution.Wash once with saturated NaCl solution. The organic phase is dried over anhydrous Na2SO4, filtered and concentrated.Column purification using DCM and PE as eluent (3:1 by volume) yielded 1.78 g of monomer m-CN-1 as a colorless oily liquid. The yield was 64.0%.
References:
Peking University;Tang Xinjing;Jin Qingqing CN107365254, 2017, A Location in patent:Paragraph 0160-0162