ChemicalBook CAS DataBase List Azido-PEG2-acid

Azido-PEG2-acid synthesis

5synthesis methods

Product Name:Azido-PEG2-acid
CAS Number:1312309-63-9
Molecular formula:C7H13N3O4
Molecular Weight:203.2

1271728-79-0
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1312309-63-9
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Yield:1312309-63-9 83%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;water for 0.583333 h;

Steps:

4 Example 4. 3-(2-(2-azidoethoxy)ethoxy)propanoic acid (87).
Example 4. 3-(2-(2-azidoethoxy)ethoxy)propanoic acid (87).The azide compound 86 (2.51 g, 9.68 mmol) dissolved in 1,4-dioxane (30 mL) and was added 10 ml of HC1 (conc.). The mixture was stirred for 35 mm, diluted with EtOH (30 ml) and toluene (30 ml) and evacuated under vacuum. The crude mixture was purified on silica gel using a mixture of methanol (from 5% to 10%) and 1% formic acid in methylene chloride as the eluant to give title compound 87 (1.63 g, 83% yield), ESI MS mlz20 C7H,2N304 (M-H), cacld. 202.06, found 202.30.

References:

SUZHOU M-CONJ BIOTECH CO., LTD;ZHAO, Robert Yongxin;ZHAO, Robert WO2015/155753, 2015, A2 Location in patent:Page/Page column 84

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756525-95-8 Synthesis