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752231-43-9

ASISCHEM W57383 synthesis

3synthesis methods
355142-36-8 Synthesis
ASISCHEM R44416

355142-36-8
18 suppliers
$121.00/250mg

ASISCHEM W57383

752231-43-9
6 suppliers
$46.00/1g

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Yield:752231-43-9 94%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 12 h;

Steps:

1.1.2.3 Compound 4c (ethyl ester of 19)

Add bromoethane (0.25mL, 3.35mmol) to 10mL DMF of 1 (700mg, 2.8mmol) and potassium carbonate (580mg, 4.2mmol), react at room temperature for 12h, extract with ethyl acetate, wash with water, and wash with saturated brine. After drying with sodium sulfate and filtering,Concentrated to obtain 730 mg of brown solid product 19 with a yield of 94%.

References:

CN111995622,2020,A Location in patent:Paragraph 0070; 0089-0091; 0096-0097

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