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ChemicalBook CAS DataBase List ASINEX-REAG BAS 03375399
38580-22-2

ASINEX-REAG BAS 03375399 synthesis

3synthesis methods
-

Yield:38580-22-2 77%

Reaction Conditions:

with water;chloroacetic acid for 24 h;Reflux;

Steps:

2

A 10% aq chloroacetic acid solution (150 ml 159 mmol) was added to 2-(6-methyl-4-oxo-2- thioxo-1 ,2,3,4-tetrahydropyrimidin-5-yl)acetic acid (7.3 g; 36.5 mmol). The mixture was stirred under reflux for 24 h and cooled in an ice-bath. The formed solid was collected by filtration, washed with water and dried under reduced pressure to give 5.17 g (77%) of the title compound as a white solid.

References:

WO2011/15641,2011,A1 Location in patent:Page/Page column 91; 92

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