Androstenone hydrazone synthesis
- Product Name:Androstenone hydrazone
- CAS Number:63015-10-1
- Molecular formula:C19H30N2O
- Molecular Weight:302.46
53-43-0
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Yield:63015-10-1 99.2%
Reaction Conditions:
with barium sulfate;hydrazine hydrate in ethanol;water at 20 - 30; for 12 h;Large scale;
Steps:
1 Example 1
In a four-necked flask, 5 kg of A0 ((3β)-3-hydroxy-5-androstene-17-one) was added, and 2,500 ml of ethanol was added.85% hydrazine hydrate 4.34g, barium sulfate 11.3g, and water 350ml were added under stirring.The reaction was carried out at 20-30°C for 12 hours (overnight) and the starting material was detected by HPLC to less than 1% or unchanged.Water 7.5kg was added to stir and crystallize for 2 hours.Rinse 1/3 (ethanol/water) and rinse with water.Drying at 50°C gave a white solid 5.2 kg.Yield: 99.2%
References:
CN104072567,2018,B Location in patent:Paragraph 0060; 0062
853-23-6
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