ChemicalBook CAS DataBase List ANANDAMIDE

ANANDAMIDE synthesis

6synthesis methods

Product Name:ANANDAMIDE
CAS Number:94421-68-8
Molecular formula:C22H37NO2
Molecular Weight:347.53

506-32-1 Synthesis

506-32-1
434 suppliers
$15.00/5g

141-43-5 Synthesis

141-43-5
889 suppliers
$9.00/10g

94421-68-8
95 suppliers
$32.00/5mg

Yield:94421-68-8 96%

Reaction Conditions:

Stage #1:all cis 5,8,11,14-eicosatetraenoic acid with 1,1'-carbonyldiimidazole in dichloromethane at 20; for 0.5 h;
Stage #2:ethanolamine in dichloromethane for 12 h;

Steps:

(21) General Procedure for Amide Coupling
General procedure: To a stirred solution of the fatty acid (1.0 mmol, 1.0 equiv.) inCH2Cl2 (5 mL) was added CDI (0.178 g, 1.1 mmol, 1.1 equiv.).After 30 min at room temperature, the amine (1.1 mmol, 1.1equiv.) was added. After 12 h, CH2Cl2 (25 mL) was added, followedby saturated aqueous NH4Cl. The mixture was acidified topH 2 by addition of HCl, the organic phase was separated, andthe aqueous layer was further extracted with CH2Cl2 (3 × 10mL). The organic phases were combined, dried over Na2SO4, filtered,and concentrated in vacuo, to give the amide.

References:

Johansson, Silje J. R.;Johannessen, Tonje;Ellefsen, Christiane F.;Ristun, Mali S.;Antonsen, Simen;Hansen, Trond V.;Stenstrom, Yngve;Nolsoe, Jens M. J. [Synlett,2019,vol. 30,# 2,art. no. ST-2018-D0672-L,p. 213 - 217] Location in patent:supporting information

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141-43-5 Synthesis

141-43-5
889 suppliers
$9.00/10g

57303-04-5 Synthesis