ACETIC ACID 5-HEXEN-1-YL ESTER synthesis
- Product Name:ACETIC ACID 5-HEXEN-1-YL ESTER
- CAS Number:5048-26-0
- Molecular formula:C8H14O2
- Molecular Weight:142.2
Yield: 97%
Reaction Conditions:
0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate in dichloromethane at -78 - 20; for 1 h;
Steps:
1.1.
To a solution of hex-5-en-1-ol (30.9 g, 309 mmol) and DMAP (41.5 g, 340 mmol, 1. 1 equiv) in CH2C12 (750 mL, 0.4 M) at-78 DEG C, was added acetic anhydride (32.1 mL, 340 mmol, 1. 1 equiv). The reaction was stirred at rt for 1 h. The product was passed through a plug of silica gel using 20 % EA/Hex to afford the desired product (42.7 g, Yield = 97 %) as a colorless oil.
References:
MERCK FROSST CANADA & CO. WO2005/70868, 2005, A1 Location in patent:Page/Page column 24
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