ChemicalBook CAS DataBase List AC-MET-OME

AC-MET-OME synthesis

5synthesis methods

Product Name:AC-MET-OME
CAS Number:35671-83-1
Molecular formula:C8H15NO3S
Molecular Weight:205.27

108-24-7
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$14.00/250ML

2491-18-1 Synthesis

2491-18-1
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$6.00/5g

35671-83-1
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$50.00/100mg

Yield:35671-83-1 94%

Reaction Conditions:

with pyridine at 20;Cooling with ice;

Steps:

4.2.1. N-Ac-l-Met-OMe

In a typical reaction, 73 mL of acetic anhydride (780 mmol) and 63 mL pyridine (780 mmol) were combined in a round-bottomed flask and chilled on ice. After 5-10 min, 8.6 g (100 mmol) l-methionine methyl ester HCl were added and the reaction mixture was allowed to slowly return to room temperature overnight. The next morning, the reaction was quenched with cold water and extracted four times with 75 mL of methylene chloride. The extracts were then rinsed three times each with 1 M HCl, saturated sodium bicarbonate solution, and water. The extracts were then dried over MgSO₄, filtered, and evaporated under reduced pressure, yielding a yellow oil which crystallized upon standing. The crude product was recrystallized in ethyl ether at -20 °C. Crystals (19.3 g, 94 mmol, 94%) were isolated by vacuum filtration. Mp = 41.7-42.4 °C. ¹H NMR ([²H]-chloroform, TMS = 0.0 ppm): δ 1.86-2.20 (m, 2H), δ 2.00 (s, 3H), δ 2.05 (s, 3H), δ 2.45-2.60 (m, 2H), δ 3.75 (s, 3H), δ 4.62-4.70 (m, 1H), δ 6.13-6.19 (bd, 1H).

References:

Foster, Michael S.;Oldham, Charlie D.;May, Sheldon W. [Tetrahedron Asymmetry,2011,vol. 22,# 3,p. 283 - 293] Location in patent:experimental part

67-56-1 Synthesis