ChemicalBook CAS DataBase List 4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester synthesis

12synthesis methods

Product Name:4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester
CAS Number:960203-42-3
Molecular formula:C23H30N2O2S
Molecular Weight:398.56

508233-74-7 Synthesis

508233-74-7
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$36.00/5mg

24424-99-5 Synthesis

24424-99-5
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$13.50/25G

4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

960203-42-3
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Yield:960203-42-3 95.1%

Reaction Conditions:

in dichloromethane at 25; for 1 h;

Steps:

2 Example 2: Preparation of 4-[2-(2,4-dimethylphenylsulfanyl)phenyl]Pyridazine-1-carboxylic acid tert-butyl ester (Formula-4)

Dissolve 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]pyridazine (Formula 3,10.0g, 3.35mmol) in 20ml of methylene chloride followed by the addition of BOC anhydride (925yl). , 4.02 mmol), start stirring and react at 25 °C for 1 h.10 ml of water was added to the reaction flask, stirred for 0.5 h, and allowed to stand and separate. The aqueous layer was extracted twice with 10 ml of dichloromethane.The organic layers were combined and the solvent was evaporated under reduced pressure to give the product 1 · 27 g. Yield: 95.1 %. 1H NMR (400 MHz, CDCl3) δ 7.36 (d, J = 8.0Ηζ, 1Η), 7.15 (s, lH), 7.10-7.09 (m, 3H), 6.87 (t, J = 8.0Ηζ, 1Η), 6.53 ( d, J = 8.0Ηz, 1Η), 3.61 (t, J = 4.0Η1, 4Η), 3.01(s, 4H), 2.36 (s, 3Η), 2.32 (s, 3H), 1 · 52 (d, J = 16Hz, 9Η) See Fig. 2 13C NMR (101ΜΗz, CDCI3) δ 154.95, 149.01, 142.36, 139.25, 136.12, 134.65, 131.71, 127.87, 127.83, 126.34, 125.54, 124.62, 119.91, 79.68, 51.63, 28.49, 21.20, 20.61 See Figure 3.

References:

CN108047162,2018,A Location in patent:Paragraph 0050; 0051

494773-35-2 Synthesis