(S)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester synthesis

4synthesis methods

Product Name:(S)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester
CAS Number:958635-19-3
Molecular formula:C16H28N2O6
Molecular Weight:344.4

(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid

788799-69-9
59 suppliers
$42.00/100mg

74-88-4
350 suppliers
$15.00/10g

(S)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester

958635-19-3
32 suppliers
$59.00/250mg

Yield:958635-19-3 95%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 0 - 20;Inert atmosphere;

Steps:

1

To a suspension of solution of (S) - l ,4bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (18.3g, 45mmol) and potassium carbonate (8,2g; 59mmol) in DMF (150ml) cooled to 0 ⁰C under N2, was added dropwise a solution of iodomethane (7.36ml; 1 18mmol). The reaction mixture was left to stir at room temperature for 18h. It was diluted with ethyl acetate, washed with water and brine. The organic was dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound as a white solid (18g; 95%). ¹H NMR (CDCl₃) 1.46-1.50 (18H, d), 1.65 (3H, s), 2.80-2.90 (I H, m), 3.10-3.40 (2H, m), 3.75-4.10 (2H, m), 4.60- 4.70 (2H, m).

References:

WO2010/11772,2010,A2 Location in patent:Page/Page column 110; 111

796096-64-5 Synthesis