4-(1-AMINO-ETHYL)-BENZOIC ACID METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:4-(1-AMINO-ETHYL)-BENZOIC ACID METHYL ESTER HYDROCHLORIDE
- CAS Number:934388-45-1
- Molecular formula:C10H14ClNO2
- Molecular Weight:215.68
![Benzoic acid, 4-[1-(hydroxyimino)ethyl]-, methyl ester](/CAS/20210305/GIF/74733-31-6.gif)
74733-31-6
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934388-45-1
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Yield:934388-45-1 83%
Reaction Conditions:
with hydrogenchloride;palladium 10% on activated carbon in methanol;water at 20;
Steps:
202
Example 202methyl 4-(1-aminoethyl)benzoate hydrochlorideTo a degassed solution of methyl 4-(1-(hydroxyimino)ethyl)benzoate (1.1 g, 5.6 mmol) and 12.0 M of hydrochloric acid in water (0.6 mL, 7.3 mmol) in methanol (50 mL) was added 10% palladium on carbon (0.20 g, 0.18 mmol). The reaction mixture was stirred overnight at room temperature. All insolubles were removed via filtration through celite and subsequent evaporation of the filtrate to dryness afforded the title compound as a white solid (1.12 g, 83%). LC-MS: (FA) ES+180; 1H NMR (400 MHz, MeOD) δ 8.09 (d, J=8.4 Hz, 1H), 7.58 (d, J=8.4 Hz, 1H), 4.55 (q, J=6.8 Hz, 1H), 3.91 (s, 3H), 1.65 (d, J=6.9 Hz, 3H).
References:
US2011/212969,2011,A1 Location in patent:Page/Page column 133
3609-53-8
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