ChemicalBook CAS DataBase List 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylamine

5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylamine synthesis

11synthesis methods

Product Name:5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylamine
CAS Number:92050-16-3
Molecular formula:C14H21N
Molecular Weight:203.32

2-Nitro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene

102121-55-1
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5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylamine

92050-16-3
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$44.00/100mg

Yield:92050-16-3 99%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethyl acetate at 70; under 1500.15 - 3750.38 Torr;

Steps:

7.a a. 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine (74)

a. 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine (74). A 0.05 M solution of1,1 ,4,4-tetramethyl-6-nitro- 1,2,3 ,4-tetrahydronaphthalene (73) (2.5 g, 10.7 mmol) in ethyl acetate(210 mL) was passed through a 10% PdJC cartridge at 1.0 mL/minute, twice, in the ThalesNano Hcube at 70 °C and 2-5 bar pressure. The resulting solution was concentrated in vacuo to give 74(2.1532 g, 99%) as a yellow, crystalline solid, m.p. 58-60 °C: ‘H NMR (400 MHz, CDC13) 7.11 (d, J= 8.4, 1H), 6.65 (d, J= 2.4, 1H), 6.54 (dd, J= 8.4, 2.4, ill), 3.62 (br s, 2H), 1.66 (s, 4H), 1.26 (s, 611), 1.25 (s, 611); ‘3C NMR (100.6 MHz, CDC13) ? 145.8, 143.3, 135.4, 127.3, 113.7, 112.9, 35.2,34.1, 33.5, 31.9, 31.7; IR (neat) 3405, 3208, 2952, 2920, 1612, 1499 cm’; LC-MS-CI (M+H)+ calcd for C,4H22N 204.1752, found 204.1747.

References:

WO2015/130973,2015,A1 Location in patent:Page/Page column 34; 35

27452-17-1 Synthesis