tert-Butyl 4-aMino-4-(4-broMophenyl)piperidine-1-carboxylate synthesis
- Product Name:tert-Butyl 4-aMino-4-(4-broMophenyl)piperidine-1-carboxylate
- CAS Number:917925-62-3
- Molecular formula:C16H23BrN2O2
- Molecular Weight:355.27
917925-61-2
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917925-62-3
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$224.00/250mg
Yield:917925-62-3 99%
Reaction Conditions:
Stage #1: 4-(4-bromo-phenyl)-4-carbamoyl-piperidine-1-carboxylic acid tert-butyl esterwith bis-[(trifluoroacetoxy)iodo]benzene in water;acetonitrile at 20; for 18 h;
Stage #2: with sodium hydrogencarbonate in water;ethyl acetate;
Steps:
H.H2
H2.4-amino-4-("4-bromo-phenylVpiperidine- 1 -carboxylic acid tert-butylesterA mixture of 4-(4-bromo-phenyl)-4-carbamoyl-piperidine-l -carboxylic acid tert-butyl ester (1.2Og, 3.13 mmol) and [bis(trifluoroacetoxy)iodo]benzene (1.38g, 3.20mmol) in acetonitrile-water (1:1, 16 ml) was stirred at ambient for 18 hours and then diluted with water (50 ml). The mixture was extracted with ethyl acetate and the combined organic EPO
References:
WO2006/136829,2006,A2 Location in patent:Page/Page column 127-128
847615-14-9
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917925-62-3
26 suppliers
$224.00/250mg