Yield:-

Reaction Conditions:

with water;lithium hydroxide in 1,4-dioxane at 23;

References:

Kort, Michael E.;Atkinson, Robert N.;Thomas, James B.;Drizin, Irene;Johnson, Matthew S.;Secrest, Matthew A.;Gregg, Robert J.;Scanio, Marc J.C.;Shi, Lei;Hakeem, Ahmed H.;Matulenko, Mark A.;Chapman, Mark L.;Krambis, Michael J.;Liu, Dong;Shieh, Char-Chang;Zhang, Xufeng;Simler, Gricelda;Mikusa, Joseph P.;Zhong, Chengmin;Joshi, Shailen;Honore, Prisca;Roeloffs, Rosemarie;Werness, Stephen;Antonio, Brett;Marsh, Kennan C.;Faltynek, Connie R.;Krafte, Douglas S.;Jarvis, Michael F.;Marron, Brian E. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 22,p. 6812 - 6815] Location in patent:scheme or table