1-(3,4-DIMETHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID synthesis
- Product Name:1-(3,4-DIMETHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
- CAS Number:862821-16-7
- Molecular formula:C12H14O4
- Molecular Weight:222.24
20802-15-7
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Yield:862821-16-7 93.5%
Reaction Conditions:
Stage #1: 1-(3,4-dimethoxyphenyl)cyclopropanecarbonitrilewith potassium hydroxide in ethylene glycol; for 12 h;Heating / reflux;
Stage #2: with hydrogenchloride;water pH=4 - 5;
Steps:
125
3.9 mmol of 1-(3,4-dimethoxyphenyl)cyclopropanecarbonitrile and 11.2 mmol of KOH were suspended in 80 mL of ethylene glycol. The mixture was stirred for 12 h under reflux. Then 80 mL of water were added and the aqueous layer was extracted two times with ether. After pH adjustment to a value of pH=4-5 using HCl (1N) the aqueous layer was extracted three times by means of ether, then the combined organic layers were dried over Na2SO4 and the solvent was removed, resulting in 0.81 g (93.5%) of 1-(3,4-dimethoxyphenyl)cyclopropanecarboxylic acid.
References:
US2008/249083,2008,A1 Location in patent:Page/Page column 41
93-17-4
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