ETHYL 2-AMINO-4-(4-BROMOPHENYL)THIAZOLE-5-CARBOXYLATE synthesis
- Product Name:ETHYL 2-AMINO-4-(4-BROMOPHENYL)THIAZOLE-5-CARBOXYLATE
- CAS Number:834885-05-1
- Molecular formula:C12H11BrN2O2S
- Molecular Weight:327.2
17356-08-0
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Yield:834885-05-1 86.7%
Reaction Conditions:
with iron(II) nitrate;pyrographite in ethanol; for 1 h;Reagent/catalyst;
Steps:
3 Synthetic method 12
General procedure: Ethyl 3-oxo-3-phenylpropionate (100 mg, 0.52 mmol), thiourea (59.4 mg, 0.78 mmol), ferrous nitrate (28.06 mg, 0.156 mmol) and activated carbon (200 mg) were added to the reaction flask , followed by adding 30 mL of anhydrous ethanol as a solvent, and stirring for 1 hour under an oxygen atmosphere.After completion of the reaction, filter and evaporate the solvent under reduced pressure; add 50 mL of water and extract with ethyl acetate; combine the organic phases and wash with saturated brine; dry over anhydrous sodium sulfate and evaporate the organic solvent under reduced pressure to obtain a crude product; the crude product After separation and purification, 104.1 mg of white solid was obtained with a yield of 80.5%.
References:
CN114057666,2022,A Location in patent:Paragraph 0090-0091; 0116-0130
26510-95-2
129 suppliers
$20.00/1g
834885-05-1
19 suppliers
$61.00/1g