ChemicalBook CAS DataBase List diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate

diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate synthesis

4synthesis methods

Product Name:diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate
CAS Number:81937-39-5
Molecular formula:C18H23NO6
Molecular Weight:349.38

63514-63-6
41 suppliers
inquiry

105-53-3
759 suppliers
$5.00/25g

diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate

81937-39-5
45 suppliers
$51.00/250mg

Yield:81937-39-5 121 g

Reaction Conditions:

with potassium tert-butylate in N,N-dimethyl acetamide at 70 - 75;Reagent/catalyst;Temperature;

Steps:

1.ii

100 g of compound I,35 g of potassium tert-butoxide,120g malonic acid diethyl ester was added to the DMA solution with stirring,Keep the reaction temperature 70 ° C ~ 75 ° C to TLC tracking of raw materials disappear.After the reaction is completed,The system is slowly poured into 1L ice water to quench,Stirring until solid precipitation,Filtered and dried to give Compound Π 121 g, a purity of 95%

References:

CN107522663,2017,A Location in patent:Paragraph 0024; 0031; 0038