8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE synthesis
- Product Name:8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE
- CAS Number:38470-28-9
- Molecular formula:C9H8FNO
- Molecular Weight:165.16
38470-19-8
19 suppliers
$35.00/250mg
38470-28-9
26 suppliers
$65.00/250mg
Yield:38470-28-9 81.63%
Reaction Conditions:
at 80; for 3 h;
Steps:
1.2 (2) Synthesis of 8-fluoro-2,3-dihydro-1H-quinolin-4-one
Take 8 mmol of the 3-(o-fluorophenylamino)propionic acid prepared in the step (1) and 280 mmol of polyphosphoric acid in a 250 mL pear-shaped bottle.After heating at 80 ° C for 3 h with mechanical stirring,Quenching the reaction with ice cubes;The resulting reaction was extracted with ethyl acetate.The organic layer was washed again with 5% NaOH.The solvent was removed using a rotary evaporator to give a crude product;The crude product is separated and purified by column chromatography.Obtaining a yellow solid product,It is 8-fluoro-2,3-dihydro-1H-quinolin-4-one,Its yield is 81.63%.
References:
CN109503478,2019,A Location in patent:Paragraph 0076; 0080-0082
348-54-9
417 suppliers
$10.00/1g
38470-28-9
26 suppliers
$65.00/250mg